This is a program Project in Basic Oncology whose aim is to marshal the efforts of basic oncologists in Colorado to explore and attempt to define the cell and molecular biology of the neoplastic transformation, and, based on the knowledge so gained, to attempt a rational approach to the diagnosis and therapy of cancer. It is a unique university-wide program which draws together the cell biologists at Boulder with the basic and clinical scientists at the University of Colorado Medical School. We have a double approach: (1) research and (2) dissemination among the participants of the latest information of basic and clinical oncology.